Oral Contraceptives Boost in glucuronidation leading to amplified plasma clearance plus a lowered half-life of acetaminophen.Concomitant use of PERCOCET with CYP3A4 inducers or discontinuation of an CYP3A4 inhibitor could lower oxycodone hydrochloride plasma concentrations, decrease opioid efficacy or, perhaps, cause a withdrawal syndrome inside of